"These parameters were chosen because handgrip strength and VO 2max provide insight into the two main categories of fitness: strength and endurance and gait speed and FEV1 provide insight into fitness-related organ function: mobility and lung function," the researchers write. In this new study, researchers developed blood-based DNAm biomarkers for fitness parameters including gait speed (walking speed), maximum handgrip strength, forced expiratory volume in one second (FEV1), and maximal oxygen uptake (VO 2max), which have modest correlation with fitness parameters in five large-scale validation datasets (average r between 0.16–0.48). However, current epigenetic clocks do not yet use measures of mobility, strength, lung, or endurance fitness in their construction.
Physical fitness is a well-known correlate of health and the aging process, and DNA methylation (DNAm) data can capture aging via epigenetic clocks.
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